「放射線安全管理、環境放射線等に関する研究

 

1.   永松知洋、花本克巳、小野俊朗、山岡聖典  埋蔵文化財発掘調査および建設工事が環境放射線に及ぼす影響に関する基礎的検討 環境制御 27: 11-16, 2005.

2.   永松知洋、花房直志、金野郁雄、迫田晃弘、花元克巳、山岡聖典、小野俊朗 岡山大学における核燃料物質の安全管理のための劣化ウランと天然ウランの鑑別について 環境制御 30: 33-37, 2008.

3.   Nagamatsu, T., Sakoda, K., Hanamoto, K., Kinno, I., Hanafusa, T., Yamaoka, K. and Ono, T. Methodological approach for assessment of the radioactivity level in dry solid waste. Radiation Safety Management 7: 6-10, 2008.

4.   Nagamatsu, T., Hanafusa, T., Ono, T. and Yamaoka, K. An assessment of the radioactivity level in 51Cr-contaminated dry solid waste generated from a research facility for verification of clearance levels. Radiation Safety Management 9: 7-12, 2010.

5.   Nagamatsu, T., Sakoda, A., Kataoka, T., Ono, T. and Yamaoka, K. An assessment of radioactivity level of 210Pb and 40K in tabacco and radiation exposure from smoking. Acta Med. Okayama 65: 91-95, 2011.

6.   Hanafusa, T., Sakoda, A., Nagamatsu, T., Kinno, I. and Ono, T. Utilization of a luminous bacterium in the teaching and learning of radiation safety. Radiation Safety Management 10: 8-13, 2011.

7.   Toyota, T., Hanafusa, T., Oda, T., Koumura, I., Sasaki, T., Matsuura, E., Kumon, H., Yano, T. and Ono, T. A purification system of 64Cu produced by a biomedical cyclotron for antibody PET imaging. J. Radioanal. Nuclear Chem. 298, 295-300, 2013.

8.   Yamashita, J., Enomoto, M., Yamada, M., Ono, T., Hanafusa, T., Nagamatsu, T., Sonoda, S. and Yamamoto, Y. Estimation of soil-to-plant transfer factors of radiocesium in 99 wild plant species grown in arable lands 1 year after the Fukushima 1 Nuclear Power Plant accident. J. Plant Res. 127: 11-22, 2014.

9.   花房直志、永松知洋、小野俊朗 自然起源放射性物質を用いた放射性同位元素の安全取扱実習 日本放射線安全管理学会誌 13, 166-172, 2014.

10. Nagamatsu,T., Hanafusa, T., and Ono, T. A simple method for sampling and measurement of radiocarbon by a passive diffusion sampling technique. Radiation Safety Management 14: 9-14, 2015.

11. 作埜秀一、大和恵子、花房直志、小野俊朗 PET核種の製造から使用における汚染及び被曝低減への取り組み 14, 91-95, 2015.

12. Nishiyama, Y., Hanafusa, T., Yamashita, J., Yamamoto, Y., and Ono, T. Adsorption and removal of storontium in aqueous solution by synthetic hydroxyapatite. J. Radioanal. Nuclear Chem. 307 (2): 1279-1285, 2016.

13. Kudo, K., Hanafusa, T., and Ono, T. In vitro analysis of radioprotective effect of monoterpenes. J. Radioanal. Nuclear Chem., DOI 10.1007/s10967-017-5268-0, 2017. 

 

 

「がん免疫に関する研究

 

1.    Ono, T., Kimura, N., Sato, S., Tanaka, N., Shibuya, A. L. J. Old and Nakayama, E. Serological analysis of BALB/c methylcholanthrene sarcoma Meth A by SEREX. Identification of a cancer/testis antigen. Int. J. Cancer 88: 845-851, 2000.

2.    Ono, T., Kurashige, T., Harada, N., Noguchi, Y., Saika, T., Niikawa, N., Aoe, M., Nakamura, S., Higashi, T., Hiraki, A., Wada, H., Kumon, H., Old, L. J. and Nakayama, E. Identification of proacrosin binding protein sp32 precursor as a human cancer/testis antigen. Proc. Natl. Acad. Sci. USA 98: 3282-3287, 2001.

3.    Yamamoto, T., Okano, M., Ono, T., Nakayama, E., Yoshino, T., Satoskai, A. R., Harn, D. A. Jr. and Nishizaki, K. Gender-related differences in the initiation of allergic rhinitis in mice. Allergy 56: 525-531, 2001.

4.    Kurashige, T., Noguchi, Y., Saika, T., Ono, T., Nagata, Y., Jungbluth, A., Ritter, G., Chen, Y.-T., Stockert, E., Tsushima, T., Kumon, H., Old, L. J. and Nakayama, E. NY-ESO-1 expression and immunogenicity associated with transitional cell carcinoma: correlation with tumor grade. Cancer Res. 61: 4671-4676, 2001.

5.    Uenaka, A., Hata, H., Win, Sanda, Ono, T., Wada, H. and Nakayama, E. ELISPOT cloning of tumor antigens recognized by cytotoxic T-lymphocytes from a cDNA expression library. Cancer Immunity 1: 8-17, 2001.

6.    Hiraki, A., Ono, T., Tanaka, M., Kiura, K., Ueoka, H., Kawai, H., Harada, M., Nakayama, E. and Noguchi, Y. Generation of cytotoxic T lymphocytes against autologous lung cancer cells resistant to apoptosis. Anticancer Research 21: 2561-2568, 2001.

7.    Ohta, S., Ono, T., Morita, A., Uenaka, A., Harada, M. and Nakayama, E. Cellular processing of a multiblunted lysine core with tumor antigen peptide and presentation of peptide epitopes recognized by cytotoxic T-lymphocytes on antigen presenting cells.  Cancer Res. 62: 1471-1476, 2002.

8.    Hata, H., Uenaka, A., Takada, I., Kenjo, A., Takahashi, M., Ono, T., Fujita, T. and Nakayama, E. Occurrence of tumor antigen pRL1a specific CD8 T cells in spleen cells from syngeneic BALB/c, semiallogeneic (BALB/c x C57BL/6)F1 and allogeneic C57BL/6 mice. Int. J. Oncol. 20: 1019-1025, 2002.

9.    Uenaka, A., Hirano, Y., Hata, H., Win, S., Aji, T., Tanaka, M., Ono, T., Skipper, J. C., Simizu, K. and Nakayama, E. Criptic CTL epitope on a murine sarcoma Meth A generated by exon extention as a novel mechanism.  J. Immunol. 170: 4862-4868, 2003.

10. Uemura, M., Nouso, K., Kobayashi, Y., Tanaka, H., Nakamura, S., Higashi, T., Ono, T., Nakayama, E., Hanafusa, T., and Shiratori, Y. Identification of the antigens predominantly reacted with serum from patients with hepatocellular carcinoma. Cancer 97: 2474-2479, 2003.

11.  Nakada, T., Noguchi, Y., Sato, S., Ono, T., Saika, T., Kurashige, T., Gnjatic, S., Ritter, G., Chen, Y.-T., Stockert, E., Nasu, Y., Tsushima, T., Kumon, H., Old, L. J. and Nakayama, E. NY-ESO-1 mRNA expression and immunogenisity in advanced prostate cancer. Cancer Immunity 3: 10, 2003.

12. Y.-T. Chen, B. Alpen, T. Ono, A. O. Gure, M. J. Scanlan, W. H. Biggs III, K. Arden, E. Nakayama, and L. J. Old  Identification and characterization of mouse SSX genes: a multigene family on the X chromosome with restricted cancer/testis expression. Genomics 82: 628-36, 2003.

13. Hasegawa, K., Ono, T., Matsushita, H., Shimono, M., Noguchi, Y., Mizutani, Y., Kodama, J., Kudo, T. and Nakayama, E. A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis. Int. J. Cancer 108: 86-90, 2004.

14. Ali El Div, A. M., Ono, T., Shimono, M., Kaneko, M., Nakagawa, K., Tanaka, R., Noguchi, Y. and Nakayama, E. Immunoscreening of a cDNA library from a lung cancer cell line using autologous patient serum: identification of XAGE-1b as a dominantl antigen and its immunogenicity in lung adenocarcinoma. Int. J. Cancer 108: 558-563, 2004.

15.    Tanaka, M., Yamada, M., Ono, T., Noguchi, Y., Uenaka, A., Ota, S., Hata, H., Harada, M., Tanimoto, M., and Nakayama, E. Inhibition of RL male 1 tumor growth in BALB/c mice by introduction of the Rlakt gene coding for antigen recognized by cytotoxic T-lymphocytes and the GM-CSF gene by in vivo electroporation. Cancer Science 95: 154-159, 2004.

16.    Sugita, Y., Wada, H., Fujita, S., Nakata, T., Sato, S., Noguchi, Y., Jungbluth, A. A., Yamaguchi, M., Chen, Y.-T., Stockert, E., Gnjatic, S., Williamson, B., Scanlan, M. J., Ono, T., Sakita, I., Yasui, M., Miyoshi, Y., Tamaki, Y., Matsuura, N., Noguchi, S., Old, L. J., Nakayama, E. and Monden, M. NY-ESO-1 expression and immunogenicity in malignant and benign breast tumors. Cancer Res. 64: 2199-2204, 2004.

17.    Tanaka, R., Ono, T., Sato, S., Nakada, T., Koizumi, F., Hasegawa, K., Nakagawa, K., Okumura, H., Yamashita, T., Ohtsuka, M., Asagoe, K., Yamasaki, O., Noguchi, Y., Iwatsuki, K., and Nakayama, E. Over-expression of a testis specific gene TSGA10 in cancers and its immunogenicity. Microbiol. Immunol. 48: 339-345, 2004.

18.    Kaneko, M., Ono, T., Matsubara, T., Yamamoto, Y., Ikeda, J., Yoshiki, T., Kawasaki, T., Furukawa, S. and Nakayama, E. Serological identification of endothelial antigens predominantly recognized in Kawasaki disease patients by recombinant expression cloning. Microbiol. Immunol. 48: 703-711, 2004.

19.    Fujita, S., Wada, H., Jungbluth, A. A., Sato, S., Nakada, T., Noguchi, Y., Doki, Y., Yasui, M., Sugita, Y., Yasuda, T., Yano, M., Ono, T., Chen, Y.-T., Higashiyama, M., Gnjatic, S., Old, L. J., Nakayama, E. and Monden, M. NY-ESO-1 expression and immunogenicity in esophageal cancer. Clin. Cancer Res. 10: 6551-6558, 2004.

20.   Sato, S., Noguchi, Y., Wada, H., Fujita, S., Nakamura, S., Tanaka, R., Nakada, T., Hasegawa, K., Nakagawa, K., Koizumi, F., Ono, T., Nouso, K., Jungbluth, A., Chen, Y.-T., Old, L. J., Shiratori, Y. and Nakayama, E. Quantitative real-time RT-PCR analysis of NY-ESO-1 and LAGE-1a mRNA expression in normal tissues and tumors, and correlation of the protein expression with the mRNA copy number. Int. J. Oncol. 26: 57-63, 2005.

21.    Hanafusa T., Shinji T., Shiraha H., Nouso K., Iwasaki Y., Yumoto E., Ono, T. and Koide N. Functional promoter upstream p53 regulatory sequence of IGFBP3 that is silenced by tumor specific methylation. BMC Cancer 5: 9, 2005.

22.    Nakagawa, K., Noguchi, Y., Uenaka, A., Sato, S., Okumura, H., Shimono, M., Ali El Div, A. M., Ono, T., Ohara, N., Yoshino, T., Yamashita, K., Tsunoda, T., Shimizu, N. and Nakayama, E. XAGE-1 expression in non-small cell lung cancer and antibody response in patients. Clin. Cancer Res. 11: 5496-5503, 2005.

23.    Matsushita, H., Uenaka, A., Ono, T., Hasegawa, K., Sato, S., Koizumi, F., Nakagawa, K., Toda, M., Shingo, T., Ichikawa, T., Noguchi, Y., Tamiya, T., Furuta, T., Kawase, T., Date, I. and Nakayama, E. Identification of glioma-specific RFX4-E and –F isoforms and humoral immune response in patients. Cancer Science 96: 801-809, 2005.

24.    Okumura, H., Noguchi, Y., Uenaka, A., Aji, T., Ono, T., Nakagawa, K., Aoe, M., Shimizu, N. and Nakayama, E. Identification of an HLA-A24-restricted OY-TES-1 epitope recognized by cytotoxic T cells. Microbiology and Immnology 49: 1009-1016, 2005.

25.    Nakamura, S., Nouso, K., Noguchi, Y., Higashi, T., Ono, T., Jungbluth, A., Chen, Y.-T., Old, L. J., Nakayama, E., and Shiratori, Y. Expression and immunogenicity of NY-ESO-1 in hepatocellular carcinoma. J. Gastroenterol. Hepatol. 21: 1281-1285, 2006.

26.    Tammela, J., Uenaka, A., Ono, T., Noguchi, Y., Jungbluth, A. A., Qian, F., Schneider, S., Sharma, S., Driscoll, D., Lele, S., Old, L. J., Nakayama, E. and Odunsi, K. OY-TES-1 expression and serum immunoreactivity in epithelial ovarian cancer. Int. J. Oncol. 29: 903-910, 2006.

27.    Kaya, S., Uenaka, A., Sato, S., Ono, T., Aji, T. and Nakayama, E. Identification of a CD4 T-cell epitope in the rejection antigen from BALB/c radiation-induced leukemia RL1. Cancer Sci. 99: 1141-1147, 2008.

28.    Domae, S., Nakamura, Y., Nakamura, Y., Uenaka, A., Wada, H., Nakata, M., Oka, M., Kishimoto, K., Tsukamoto, G., Yoshihama, Y., Matsuoka, J., Gochi, A., Saika, T., Kohno, S., Sasaki, A., Nakayama, E. and Ono, T. Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity. Int. J. Cancer 124: 2347-2352, 2009.

29.    Fukazawa, T., Maeda, Y., Matsuoka, J., Ono, T., Mominoki, K., Yamatsuji, T., Shigematsu, K., Morita, I., Murakami, I., Tanaka, H., Durbin, M. L. and Naomoto, Y. Targeting KRAS mutation-bearing lung cancer in vivo by pulmonary surfactant-adenovirus-mediated gene transfer. Anti Cancer Res. 30: 4925-4935, 2010.

30.    Hanafusa, T., Ali Eldib, A. M., Kitaoka, K., Ohue, Y., Nakayama, E. and Ono, T. Isolation and characterization of human lung cancer antigens by serological screening with autologous antibodies. Cancer Letters 301: 57-62, 2011.

31.    Hanafusa, T., Ali Eldib, A. M., Domae, S., Nakayama, E. and Ono, T. Serological identification of Tektin5 and its immunogenicity. BMC Cancer 12: 520, 2012.

32.    Domae, S., Ono, T. and Sasaki, A. Cancer/testis antigens: A prospective reagent as diagnostic and immunotherapeutic targets for squamous cell carcinoma of the head and neck. Jpn. Dent. Sci. Review 50: 91-99, 2014.

33.    Takakura, H., Domae, S., Ono, T. and Sasaki, A. The immunological impact of chemotherapy on the tumor microenvironment of oral squamous cell carcinoma. Acta Medica Okayama, 2017, in press.